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The Histamine H3 Receptor

A Target for New Drugs

In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive. The H3 receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). Both the H3 agonist and the H3 antagonist cause important pharmacological effects. Several ligands have become available now, including radiolabelled analogues. In this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H3 receptor and the several ligands available are presented by a number of experts in the field. The book presents an extended review of what has happened since the first H3 paper appeared. The editors hope that publication of this work will lead to an increase in interest of both academia and industry for the H3 receptor, especially as a target for drug development.

In this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H3 receptor and the several ligands available are presented by a number of experts in the field.

Ironi & sarkasme bahasa politik media

filsafat analitik John Langshaw Austin

Speech acts aspects in Mr. Pecut column in Jawa Pos daily, Indonesia.

Dinamika kota tambang Sawahlunto

dari ekonomi kapitalis ke ekonomi rakyat

Historical development of Sawahlunto, a mining city in West Sumatera.

Historical development of Sawahlunto, a mining city in West Sumatera.

PERBANDINGAN PENDIDIKAN

Buku ini merupakan hasil karya yang dapat dijadikan sumber belajar bagi mahasiswa sebagai dasar dalam melakukan pembelajaran. Buku ini diharapkan dapat memberikan kontribusi pada pengembangan ilmu pengetahuan di bidang akademisi sehingga menjadi buku yang signifikan. Untuk memudahkan pembaca dalam memahaminya, penulis menyusun buku ini dalam beberapa bagian bab.

Dari aspek klimatologis nampaklah pengaruhnya terhadap perbedaan sistem operasionai kependidikan yang berhubungan dengan batas-batas usia masuk sekolah, bentuk bangunan, serta fasilitas pendidikan yang diperlukan. 3. Faktor Ekonomi ...

Teori dan Aplikasi Bahasa Indonesia

Bahasa merupakan salah satu unsur identitas suatu bangsa. Begitu pula Bahasa Indonesia merupakan salah satu identitas nasional bagi bangsa dan negara Indonesia. Bahasa Indonesia adalah bahasa resmi Republik Indonesia dan bahasa persatuan Bangsa Indonesia. Bahasa Indonesia diresmikan penggunaannya satu hari setelah Proklamasi Kemerdekaan Indonesia, tepatnya pada tanggal 18 Agustus 1945 bersamaan dengan mulai berlakunya Undang-undang Dasar Republik Indonesia 1945.

Bahasa merupakan salah satu unsur identitas suatu bangsa.